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Wobenzym® N has been used in the treatment of infertility for a number of reasons. First, elevated cytokines – which are frequently seen in infertility - interfere with normal function of the hypothalamic-pituitary axes. This results in altered production of pituitary hormones that are critical for fertility. So, the one benefit of Wobenzym® N is the normalization of the hypothalamic-pituitary-gonadal axis.
Another benefit would be an improvement of immunologically caused habitual miscarriages, which can be because of either autoimmune or alloimmune dysfunction. In autoimmune infertility, the miscarriage is because of autoimmune inflammation that prevents proper function of the placenta due to inflammation. In alloimmune miscarriages, the mothers immune system is so unstable due to abnormal inflammatory action that it actually attacks the fetus and causes the miscarriage.
The literature reveals that Wobenzym is an effective therapy got forth autoimmune and alloimmune miscarriages. One study showed that 124 out of 144 women who had habitual immunologically caused miscarriages were able to get pregnant and give birth to 114 healthy children. Those are pretty impressive results.
                                From FREQUENTLY ASKED QUESTIONS, with answers by Joseph J Collins, RN, ND
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What the literature says about Systemic Enzyme Support and:


Immunomodulation in the treatment of reproduction disturbances

Nouza K., Madar J. Immunomodulation in the treatment of reproduction disturbances. American Journal of Reproductive Immunology 2001, Vol. 46, No. 1, pp. 106, Abst. WP8-3 541 KA Institute for the Care of Mother and Child, Prague, Czech Republic. VIII International Congress of Reproductive Immunology, Opatija, Croatia, July 2 – 6, 2001  

Immune mechanisms play an important role in both male and female sterility. Even more frequent is the participation of immunity in autoimmune and alloimmune recurrent abortions. Immunopathologic reactions occur also in women suffering from preeclampsia and postclimacteric syndrome. To the important causes of female and male sterility belong chronic infections in the reproductive system.
Methods of Study
Treatment of all above mentioned disorders involved methods of immunomodulation, mainly local and systemic glucocorticoids, repeated high doses of intravenous immunoglobulines, anticoagulants (aspirin, heparin) and recently also oral enzyme therapy. In infectious processes, the rational use of antibiotics is inevitable.
Immunomodulation ameliorates healing of male and female sterility, autoimmune as well as alloimmune recurrent abortions. Significant progress was also obtained in the treatment of adnexitis and prostatitis. Here, the clinical or subclinical immunological defect prompted us to use immunomodulators of chemical or biologic nature (among the latter, combination of oral animal and plant proteolytic enzymes). Their use in combination with antibiotics led to a more frequent and more effective healing not only in the infections evoked by "common" bacteria, but also in processes caused by chlamydia, mycoplasma, and ureaplasma.Conclusion
Immunomodulation represents an important part of the complex therapy of male and female sterility, recurrent abortions and chronic infections of the reproductive system.
Poster Reference Number 60.  

Systemic enzyme therapy in the treatment of chronic salpingitis and infertility.  

Ivaniyta L.I., Ivaniyta S.O., Kornatskaya A.G., Belis N.I., Kondratiyk. Systemic enzyme therapy in the treatment of chronic salpingitis and infertility. Farm. Zh. (Kiev) 1998, No. 2, pp. 89-92. Institute of Pediatrics, Obstetrics, and Gynecology, Ukraine. [Ukrainian, Czech]  

30 women, mean age 26.5 years, with chronic salpingitis and infertility were observed. 18 women suffered from primary infertility, 12 from secondary one. 21 patients were previously treated (antiinflammatory, hormonal therapy). 27 patients were diagnosed with unilateral salpingitis, 3 with bilateral one.Treatment started after activation of chronic inflammatory process. First, pyrogenal was administered, followed by antibacterial, anticandidous, desensibilization, and vitamin therapy. Together with antibiotics, Wobenzym was administered at the dose of 5 dragees 3 times a day for 10 days. Patients in the control group received the same therapy without Wobenzym.
Already after 5-6 days of Wobenzym treatment, an improvement of patients' condition was observed. Frequency and intensity of abdominal pain and in 86.4 % normalization of body temperature, appetite and intestinal function was seen. Positive changes of inflammatory signs were found after treatment - decreased infiltration, disappearance of pain on palpation. Positive status was verified also by blood parameters: leukocyte count decreased from 8.0 ± 0.3 x 109 to 6.3 ± 0.1 x 109. Sedimentation normalized and concentration of C-reactive protein decreased under Wobenzym treatment. Above described parameters did not change in the control group.
In 20 out of 22 patients, normalization of microflora was found. Impaired menstrual cycle normalized in 75 % patients.
Poster Reference Number 61.  

Enzyme therapy - a method of immune therapy for immunologically caused habitual abortions  

Dittmar, F.-W. Enzyme therapy - a method of immune therapy for immunologically caused habitual abortion. Forum Immunologie 2000, No. 3/2000, II - VIII. SO 129 (5-02-1) Gynäkologisch-geburtshilfliche Abteilung (Chefarzt: Prof. Dr. F.-W. Dittmar) des Kreiskrankenhauses Starnberg, Akademisches Lehrkrankenhaus der Ludwig-Maximilians-Universität München  

Background: For patients with immunologically caused habitual abortion so far there are only few therapies possible with limited success and predominantly considerable side effects.
Objective: it was the aim of this investigation to rate the benefit of systemic enzyme therapy for pregnant women with habitual abortion in history by means of the course of pregnancy and delivery including fetal outcome. Materials and methods: 144 pregnant women with immunologically caused abortion received a gestagen preparation and an enzyme combination preparation and were observed up to delivery. The current data of pregnancy, birth and child were collected and evaluated.
Results: 114 of 144 enzyme treated pregnant women had an inconspicuous course of pregnancy up to the. birth of 114 healthy children. Enzyme therapy caused no unpleasant side effects. 
Conclusions: For immunologically caused habitual abortion enzyme therapy is an effective form of immune therapy. The maternal immune system is stabilized by the supplied enzymes whereby the full development of a pregnancy is easier. The further clearing of the molecular mechanisms of action is subject of current research projects. Enzyme therapy can be recommended predominantly for women, who had several abortions receiving the common forms of immune therapy without success and therefore now are looking for a therapeutical alternative. According to the previous experience enzyme therapy is very successful for women with habitual abortion with regard to completed pregnancies, and furthermore well tolerated and also cost-effective.
Key words: Enzyme therapy • immune therapy • habitual abortion
Poster Reference Number 62.  

The use of WOBENZYM® to facilitate interferon synthesis in the treatment of chronic urogenital chlamydiosis.  

Sukhikh G.T., Loginova N.S., Faizullin L.Z., Zdanov A.V, Malinina E.V, Bozedomov VA. The use of WOBENZYM® to facilitate interferon synthesis in the treatment of chronic urogenital chlamydiosis. Inter. Journal of Immunotherapy 1997, Vol. XIII, No. 3/4, pp 131-133, ISSN 0255-9625 SO 112 (19-04-2) - (5-02-2) Scientific Center of Obstetrics, Gynecology and Perinatology of the Russian Academy of Medical Sciences and the International Institute of Biological Medicine, 117815, 4 Oparin Street, Moscow, Russia. 7th Interscience World Conference on Inflammation, Antirheumatics, Analgesics, Immunomodulators, 1997, May 19-21, Geneva, Switzerland. [Czech] 

Chlamydial infections are recognized as a major cause of infertility in couples and different types of pathology of male and female reproductive functions.
Female endocervical smears and male urethral swabs were examined by polymerase chain reaction (PCR) in 3,200 patients. Optimal schedule of treatment of chronic urogenital chlamydiosis using proteolytic enzymes (peroral tablet of Wobenzym®, Mucos Pharma, Geretsried, Germany) were proposed by us. In order to realize the mechanism of the therapeutic effect of proteinases we investigated the changes in the interferon system of patients. We found significant decrease of IFN a-g production and increase of serum IFN. Application of Wobenzym® led to normalization of leukocyte capability to synthesize IFN in response to all inductors. Standard antibiotic therapy led to chlamydia elimination in 61 % women and 45% men; combination of antibiotic therapy with Wobenzym® resulted in 92% cases with women and 89.5% with men, respectively. The blockade of interferon synthesis by leukocytes seems to be the cause of long-term prolongation of chlamydial infection inducing inflammation in the genital tract. Proteinases coming into the blood relieve the blockade of non-specific antibacterial defense. Thus, proteolytic enzymes were shown as a highly efficient strengthening factor for antibiotic therapy of urogenital chlamydiosis.  

Our experience with systemic enzyme therapy in the complex treatment of urogenital chlamydiosis.  

Yakimova A.V., Zakharova Yu.V., Skuratov S.I., Khokhlov V.V. Our experience with systemic enzyme therapy in the complex treatment of urogenital chlamydiosis. Presented at the conference “Current approaches in diagnostics and treatment of urogenital chlamydiosis”, Novosibirsk, 1998 Medical Institute, Novosibirsk, Russia [Russian] Presented at the conference “Current approaches in diagnostics and treatment of urogenital chlamydiosis”, Novosibirsk, 1998  

To increase the efficacy of chronic chlamydiosis treatment, Wobenzym was included into the therapy. 19 women and 10 men suffering from inflammatory diseases of urinary and genital organs and/or infertility caused by Chlamydia trachomatis were observed.
All patients underwent a complex etiotropic and pathogenetic therapy. Wobenzym was used in combination with conventional antibiotics (tarivid, rovamycin, doxycyclin). Wobenzym was administered orally 5 dragees 3 times a day.Complete clinical healing with elimination of Chlamydia was achieved in 79.3% patients. Rest of patients reported improved condition, although Chlamydias were still present. No Wobenzym side-effects were seen.