Sports Medicine
|
There are a number of
ways that athletes benefit from regular use of Wobenzym®
N. The first would be the ability of Wobenzym® N
to improve athletic performance by decreasing the
inflammatory consequences of that intense physical activity
brings about. While the demands of athletic performance tend
to improve physical health and cumulatively improve further
athletic performance, over training and excessive strain
leads to tissue damage with the undesirable consequence of
inflammation. Most of us have experienced the increased achiness that is common after exercise – sometimes it shows up a couple of days after the workout. This represents a degree of inflammation that the body has to recover from. Think of this a micro-trauma. There is not a bruise, sprain or broken bone, but there is inflammation. Now, as far as the body is concerned, inflammation is inflammation – so the body’s resources are being used to react to that inflammation. Specifically; cytokines – those inflammation promoting molecules we have talked about – are increased after intense physical exercise. As we discussed earlier, Wobenzym® N decreases pro-inflammatory cytokines. As such, it shortens the duration of post exercise inflammation. The excellent results have been observed in athletes using Wobenzym® N can be explained by its ability to interfere with the inflammation caused by athletic micro-trauma. In this fashion, it improves recovery time. From FREQUENTLY ASKED QUESTIONS, with answers by Joseph J Collins, RN, ND Read the special section: TRAUMA, SURGERY, SPORTS MEDICINE & WOBENZYM® |
What
the literature says about Systemic Enzyme Support and:
Sports Medicine
Physical activity and immune system. Systemic enzyme therapy in
prevention and treatment.
Nouza K. Physical activity and immune system. Systemic enzyme
therapy in prevention and treatment. Medicina Sportiva Boh. Slov.
1997, Vol. 6., No. 2, pp. 41 - 45
Summary
Besides serious infections, injuries. burns and irradiation, stress
is also provoked by a strong physical tension, excessive training
and heavy competition rate - factors of professional sporting
activity. An important consequence of stress is on affliction of the
immune system, its factors and functions, leading secondarily to a
decrease of antiinfectious resistance and antitumor surveillance.
While experimental as well as medical experience indicate that
regular exercise and recreation sport affects immune system and its
function favourably, overtraining, and excessive strain lead to its
damage with undesirable consequences. A higher sensitivity to
infections is the most prominent: several small-range epidemics have
been announced. The paper summarizes main information about changes
in the immune system in professionals accomplishing demanding sports
- marathon runners, karatists, skiers, cyclists and others. The
immune cells (granulocytes, lymphocytes, monocytes, NK) react after
an early temporal mobilization with a decline in numbers as well as
in functional activities. Similarly, blood levels of immunoglobulins
(notably IgA) tend (after a short-time increase) to fall down, often
for prolonged time period; the same applies to factors of natural
immunity. As underlying mechanisms of these effects there are
stress-mediated disturbances of homeostasis, overproduction of some
cytokines, adhesive molecules, and toxic radicals.
Among preventive and therapeutic procedures the attention is paid
mainly to combination of proteolytic enzymes. Surprisingly excellent
practical results may be satisfactorily explained by selective
interferences of enzymes with the pathophysiologic mechanisms of
inflammation and by their complex immunomodulatory (immunonormalizing)
effects.
Key
words: sport, stress, disturbance of immunity, systemic enzyme
therapy
Prophylactic administration of Wobenzym to reduce consequences of
sports injuries in karate fighters.
Zuschlag J.-M. Prophylactic administration of Wobenzym to reduce
consequences of sports injuries in karate fighters. MUCOS Pharma
GmbH & Co, Dept. Clinical Research, Geretsried, Germany.
In
a double blind, placebo controlled, randomised clinical trial the
efficacy and tolerance of WOBENZYM® adminstration was proved to
reduce the consequences of sports injuries in top sportsmen.
20
karate fighters, aged between 13 and 21 years, who underwent a
regular training, were included into the trial. 10 volunteers
received in the Phase I Wobenzym tablets and in the Phase II
placebo, whereas other 10 sportsmen received in the Phase I placebo
and in the Phase II Wobenzym.
Main evaluation criteria were training absence and absence at work
or at school.
Other criteria were duration of hematomas, edema, rest pain, pain on
movement, pain on pressure, restricted motility and general
inflammatory reactions.
Frequency as well as severity of symptoms were comparable in both
groups.
However, their duration was statistically significantly shorter
under Wobenzym treatment. Evaluation of main criteria was
statistically significantly better in the enzyme group (training
absence 2.2 days compared to 9.5 days in the placebo group, p = 2.87
x 10-6; absence at work or at school 0.2 days compared to 1.8 days,
p = 0.024). Evaluation of all other criteria showed statistically
significantly better result in the enzyme group as compared to the
placebo group (p < 0.001).
One
case of adverse events was reported in the enzyme group: a slight
diarrhea which lasted for five days and did not require any changes
of the therapy. There was a possible association with Wobenzym
treatment.
In
the study it has been proven that prophylactic administration of
Wobenzym (3x5 tablets daily) in top sportsmen showing a higher risk
of injury significantly reduces duration of injury symptoms and
training and work absence as a consequence of such injuries.
Poster Reference Number 78.
A
double blind, randomised, parallel group study on the efficacy and
safety of treating acute lateral ankle sprain with oral hydrolytic
enzymes.
Kerkhoffs GM, Struijs PA, de Wit C, Rahlfs VW, Zwipp H, van Dijk CN.
A double blind, randomised, parallel group study on the efficacy and
safety of treating acute lateral ankle sprain with oral hydrolytic
enzymes. Br J Sports Med. 2004 Aug;38(4):431-5.
OBJECTIVE: To compare the effectiveness and safety of the triple
combinationPhlogenzym (rutoside, bromelain, and trypsin) with double
combinations, thesingle substances, and placebo. DESIGN:
Multinational, multicentre, double blind,randomised, parallel group
design with eight groups structured according to afactorial design.
SETTING: Orthopaedic surgery and emergency departments in 27European
hospitals. PARTICIPANTS: A total of 721 patients aged 16-53
yearspresenting with acute unilateral sprain of the lateral ankle
joint. PRIMARYEFFICACY CRITERIA: (a) Pain on walking one or two
steps, as defined by thepatient on a visual analogue scale. (b) The
range of motion, as measured by theinvestigator and expressed as a
sum of flexion and extension. (c) The volume ofthe injured ankle
measured with a volometer. RESULTS: At the primary end point atseven
days, the greatest reduction in pain was in the bromelain/trypsin
group(73.7%). The Phlogenzym group showed a median reduction of
60.3%, and the placebogroup showed a median reduction of 73.3%. The
largest increase in range of motion(median) was in the placebo group
(60% change from baseline). The Phlogenzymgroup showed a median
increase of 42.9%. The biggest decrease in swelling was in the
trypsin group (3.9% change from baseline). The Phlogenzym group
showed a-2.30% change from baseline and the placebo group a -2.90%
change. In thesubgroup analysis of patients who did not use a
Caligamed brace, Phlogenzym wassuperior to placebo for the
summarising directional test of the primary efficacy criteria (MW =
0.621; LB-CI 0.496; p = 0.029; one sided Wei-Lachin procedure).The
vast majority of doctors and patients rated the tolerability of
alltreatments tested as very good or at least good.
CONCLUSIONS: Phlogenzym was not found to be superior to the three
two-drug combinations, the three singlesubstances, or placebo for
treatment of patients with acute unilateral sprain of the lateral
ankle joint. The small subgroup of patients treated without
thesupport of a Caligamed brace showed evidence of superiority of
Phlogenzym overplacebo. Further research is warranted to study this
effect of Phlogenzym inpatients treated without ankle support.
External Link:
PMID: 15273178
Physical activity and immune system. Systemic enzyme therapy in
prevention and treatment.
Nouza K. Physical activity and immune system. Systemic enzyme
therapy in prevention and treatment. Medicina Sportiva Boh. Slov.
1997, Vol. 6., No. 2, pp. 41 - 45
Summary
Besides serious infections, injuries. burns and irradiation, stress
is also provoked by a strong physical tension, excessive training
and heavy competition rate - factors of professional sporting
activity. An important consequence of stress is on affliction of the
immune system, its factors and functions, leading secondarily to a
decrease of antiinfectious resistance and antitumor surveillance.
While experimental as well as medical experience indicate that
regular exercise and recreation sport affects immune system and its
function favourably, overtraining, and excessive strain lead to its
damage with undesirable consequences. A higher sensitivity to
infections is the most prominent: several small-range epidemics have
been announced. The paper summarizes main information about changes
in the immune system in professionals accomplishing demanding sports
- marathon runners, karatists, skiers, cyclists and others. The
immune cells (granulocytes, lymphocytes, monocytes, NK) react after
an early temporal mobilization with a decline in numbers as well as
in functional activities. Similarly, blood levels of immunoglobulins
(notably IgA) tend (after a short-time increase) to fall down, often
for prolonged time period; the same applies to factors of natural
immunity. As underlying mechanisms of these effects there are
stress-mediated disturbances of homeostasis, overproduction of some
cytokines, adhesive molecules, and toxic radicals.
Among preventive and therapeutic procedures the attention is paid
mainly to combination of proteolytic enzymes. Surprisingly excellent
practical results may be satisfactorily explained by selective
interferences of enzymes with the pathophysiologic mechanisms of
inflammation and by their complex immunomodulatory (immunonormalizing)
effects.
Key
words: sport, stress, disturbance of immunity, systemic enzyme
therapy Poster Reference Number 80.
Use
of systemic enzyme therapy in the treatment of hand injuries and
their consequences.
Naumenko L. Yu. Use of systemic enzyme therapy in the treatment of
hand injuries and their consequences.Presented at the conference
”Current treatment aspects of wrist injuries and their
consequences”, Dnepropetrovsk 1998
Wobenzym was administered to the 3 groups of patients (total 52)
with various hand traumas:
Consequences of
traumas which needed reconstructive surgery – 15 patients
Acute hand traumas –
27 patients
Hand diseases – 10
patients
Wobenzym was administered according to the standard scheme – 7-10
dragees 3 times a day.
Patients in the 1st group were treated preoperatively (7 days before
surgery) and subsequently over 12 days postoperatively. Preoperative
treatment showed a positive influence on edema and pain syndrome
during a postoperative period.
In
Wobenzym-treated patients, edema decreased during 7 preoperative
days to 27% (in comparison to 53% in the control group). During
early postoperative period edema increased to approx. 60% of the
initial condition (compared to the 100% in the control group).
Within 12 days after surgery, edema decreased to 7% of the initial
condition (19% in the control group). A fast regression of pain
syndrome in the Wobenzym-treated patients enabled a discontinuation
of analgesic drugs from 2-3 days after surgery.
Patients in the 2nd group were treated with Wobenzym for 1 month
(longer treatment because of trauma severity). Characteristics of
edema and pain syndrome development were similar to that of the 1st
group.
Patients in the 3rd group were treated with Wobenzym for 2-3 months.
A salutary effect of enzyme therapy in combination with
anti-edematous and analgesic drugs occurred during II-III weeks of
treatment. Wobenzym treatment led to a significant decrease of CRP
and sedimentation.
Wobenzym was well tolerated by most of the patients. Side-effects
occurred in 2 patients and disappeared after dose lowering.
Poster Reference Number 81.