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Frequently Asked Questions

HORMONES & WOBENZYM®

How can Wobenzym® be used for the treatment of hormone imbalances?

What I see in Wobenzym® N is the answer to a key component of hormonal imbalances – specifically: the ability to effectively control the inflammation that is related to hormone imbalances. What we now understand, is that those pro-inflammatory cytokines that we have talked about – such as interleukin 6 and TNF-alpha – are elevated in conditions that are primarily considered as endocrine problems.
We see elevations of these cytokines in menopause, hypothyroidism, polycystic ovary disease, insulin resistance, diabetes,
infertility and even adrenal fatigue and stress disorders.
We also know that elevated pro-inflammatory cytokines interfere with normal function of the hypothalamic-pituitary axes.
Specifically, these cytokines inhibit the activity of the hypothalamic-pituitary-adrenal axis – causing abnormal circadian (24 hour) rhythms, and predisposing to, or perpetuating fatigue disorders.
We know that inflammatory cytokines inhibit the activity of the hypothalamic-pituitary gonadal (HPG) axis at various levels and that this dysregulation of the gonadal axis may chronically lead to reproductive dysfunction and reduced fertility.
[PMID19121989] We also know that inflammation can have a direct affect on the function of ovaries and testes and negatively affect fertility.
Thyroid function can likewise be negatively affected. Elevations of pro-inflammatory cytokines interfere with normal hypothalamic-pituitary-thyroid axis function. In addition, the cells within the thyroid – the thyrocytes have diminished ability to function due to this systemic inflammation. In fact, controlling systemic inflammation may be the most important therapy in overcoming subclinical hypothyroidism. There is already no doubt in my mind that Wobenzym should always be considered for
autoimmune thyroid disease.


What role does Wobenzym® play in the treatment of thyroid disease.
Autoimmune hypothyroidism (Hashimoto’s) – the most common cause of hypothyroidism - is a condition that can be somewhat difficult to successfully treat due to the chronic inflammation taking place in that condition. Even after the patient’s hormone levels have been increased back to normal with prescription thyroid replacement, we still see many clinical signs of hypothyroidism.
For instance, even after thyroid hormone replacement, patients can still have elevated cholesterol and triglycerides. However, when patient were given 5 Wobenzym tablets, 3 times a day – in addition to their thyroid replacement – their cholesterol and triglycerides decreased. The patients that were only given thyroid replacement still had elevated cholesterol and triglycerides.
We also noted that taking Wobenzym resulted in a reduction of autoimmune antibodies that attack the thyroid – the anti-TG and anti-TPO antibodies. Since the thyroid is no longer under attack from the immune system, it is able to resume making thyroid hormones that way that it should. As a result, there was also a reduction of TSH levels. As a result, patients that received Wobenzym as part of their therapy were able to lower their dosage of thyroid medication after 3 months. In some cases, the thyroid medication could be completely discontinued.
Based on what we now know, I would say that this is possible because of Wobenzym’s beneficial effect on the hypothalamic-pituitary-thyroid axis, - its effect on the thyroid tissue itself – and its effect on the immune system - the elimination of autoimmune destruction of the thyroid.
The pro-inflammatory cytokines that we see in both autoimmune disease and in systemic inflammation have a very detrimental effect on thyroid function on so many levels. If we keep in mind that the first word in the phrase “autoimmune thyroid disease” is “autoimmune” we will have a better understanding of why the immunomodulating properties of Wobenzym® N are so effective in treating
autoimmune hypothyroidism.

What affect does Wobenzym® therapy have on the development and progression of diabetes?
When Wobenzym was added to the therapies for children with type 1 diabetes, we see lower HbA1c, and higher levels of C-peptide. When there is an increase in C-peptide, a marker of how much insulin the pancreas can still make, there is decreases the onset and progression of the
complications of diabetes such as diabetic neuropathy. By helping the body raise c-petide levels, Wobenzym also decreases the risk and progression of diabetes kidney disease a very common complication that can occur with diabetes. That is just one the benefits that Wobenzym® has for diseases of the kidneys.
Animal studies on development of
diabetes demonstrate that Wobenzym® PS decreases the development of antibodies against pancreatic islet cells.

Why has Wobenzym® been used for infertility?
Wobenzym® N has been used in the treatment of
infertility for a number of reasons. First, elevated cytokines – which are frequently seen in infertility - interfere with normal function of the hypothalamic-pituitary axes. This results in altered production of pituitary hormones that are critical for fertility. So, the one benefit of Wobenzym® N is the normalization of the hypothalamic-pituitary-gonadal axis.
Another benefit would be an improvement of immunologically caused habitual miscarriages, which can be because of either autoimmune or alloimmune dysfunction. In autoimmune infertility, the miscarriage is because of autoimmune inflammation that prevents proper function of the placenta due to inflammation. In alloimmune miscarriages, the mothers immune system is so unstable due to abnormal inflammatory action that it actually attacks the fetus and causes the miscarriage.
The literature reveals that Wobenzym is an effective therapy got forth autoimmune and alloimmune miscarriages. One study showed that 124 out of 144 women who had habitual immunologically caused miscarriages were able to get pregnant and give birth to 114 healthy children. Those are pretty impressive results.

How else can Wobenzym® be used in women’s health?
Quite a few conditions are improved by adding Wobenzym to the treatment plan. We see it used with various forms of both acute and chronic
pelvic inflammatory disease.
Wobenzym® is very effective therapy for the management of fibrocystic breast disease, especially since it does not interfere with already upset hormonal balance that typically accompanies fibrocystic breast disease.

What about men? Does it help with prostate problems?
In men, Wobenzym® is a very efficient therapy for both bacterial and abacterial
prostatitis, and also relieves the sexual dysfunction that typically accompanies prostate diseases.

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