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Frequently Asked Questions


How can Wobenzym decrease the risk of developing kidney stones?
In the most severe cases of kidney stones - patients that need surgical intervention to remove the stones – taking the systemic enzymes made them significantly less likely to get stones again.
Now what is interesting is that in those studies, the patients took enzymes for only four to five weeks – but they still had less risk of developing new kidney stones a year later!!
From what I have been able to find in the literature, I would say that by decreasing inflammation (and decreasing pro-inflammatory cytokines such as IL-6 – which is associated with kidney stone formation) , and pro-Wobenzym is able to inhibit the development of kidney stones decrease the inflammatory.
But more than that, the enzymes in Wobenzym have proteolytic properties may decrease formation of the organic (protein) component of the kidney stone. In addition, the enzymes appear to be interacting with bikunin, a glycoprotein that is a member of the inter-alpha-trypsin inhibitor (ITI) family. Like alpha-2-macroglobulin, the ITI family of glycoproteins modulate inflammation. Proper function of bikunin decreases calcium oxylate stone formation.
We also note that patients with kidney stones complicated by pyelonephritis have very high levels of SIgA (secretory IgA) an immunoglobulin involved in local immunity of mucus membranes. This increase in the urine level of SIgA in patients with kidneys stones and pyelonephritis can play apart in the development of kidney stones. By normalizing urinary system local immunity, Wobenzym can decreases kidney stone formation. So, there are a number of mechanisms by which Woebnzym-N can decrease
kidney stone formation.

How are kidney infections improved by using Wobenzym®?
In a study of 66 patients with chronic
pyelonephritis, Wobenzym yielded results that “considerably exceeded those in conventional drug treatment.” This was evidenced by both clinical findings (symptoms) as well as laboratory findings.
One reason for the notable benefit would be due to the normalization of urinary system local immunity, as we just discussed.
Now I will be the first to admit that kidney infections are serious conditions, and antibiotic therapy is very appropriate therapy. But what we have observed is that chronic and recurrent infections – infections that are resistant to improvement even on antibiotics – do much better – and can be resolved when Wobenzym is added to the treatment plan. Other conditions that are often resistance to antibiotic therapy and benefit from this systemic enzyme therapy also include and recurrent urinary tract infections, a very common problem of the urinary system.

Is Wobenzym useful for treating urinary tract infections?
Adding enzyme therapy to the antibiotic therapy dramatically shortens the time that it takes both feel better, and for lab tests to show a decrease in the systemic inflammation that accompanies a
urinary tract infection. This has been observed in the recurrent urinary tract infections – which have traditionally been very hard to treat –even with antibiotics and other drugs.
Keep in mind, these recurrent urinary tract infections are notorious for being hard to treat and hard to keep coming back. The fact that we can use Wobenzym to make antibiotics more effective – and to prevent re-infection – is a very important point.
When we use Wobenzym to make antibiotic more effective we are using the adjuvant properties of Wobenzym. An adjuvant is a substance that significantly improves the effective of other therapies that have limited effectiveness. Wobenzym has been used as an adjuvant to treat a number of inflammatory and infectious diseases. This hold true for not only
recurrent urinary tract infections and pyelonephritis, but also for recurrent respiratory tract infections, as well as chronic infections of the reproductive system.

How does Wobenzym® help glomerulonephritis?
The benefits of Wobenzym® in regards to the treatment of
glomerulonephritis is due to many beneficial actions of Wobenzym® including among other actions, its antioxidant effect, its anti-inflammatory functions, and its ability to restore normal lipid (fats) metabolism. One study concludes that Wobenzym® is the drug of choice, decreasing the velocity of kidney destructive processes. [ more ]

How does Wobenzym® help with diabetic kidney disease?
We know that Wobenzym can increase levels of C-peptide in autoimmune mediated diabetes, such as type 1 diabetes. In addition to showing much insulin the pancreas can still make, C-peptide decreases the progression so the common complications of diabetes, including the diabetic nephropathy.
We also note that systemic enzymes can decrease the formation of “advanced glycation end products” (AGEs), which are associated with diabetic nephropathy and other complications of diabetes.
IN addition, abnormal cytokines levels are normalized, including transforming growth factor beta-1 (TGF-b1), and interleukin 6.
What we have come to realize, is that the complications of diabetes are strongly mediated by the immune system. We see that controlling blood sugar with insulin is not enough to prevent complications such as diabetic nephropathy. The abnormal cytokine levels that occur with diabetes can safely and effectively be normalized with Wobenzym.
This normalization of immune function is why Wobenzym should also be used in other kidney diseases such as kidney stones, frequent urinary tract infections and pyelonephritis.

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