The local immunity of the urinary system in patients with recurrent Urolithiasis
Borisov AV. The local immunity of the urinary system in patients
with recurrent Urolithiasis. Lik Sprava. 1999 Apr-May;(3):111-5.
51 patients with urolithiasis complicated by pyelonephritis in the
active phase of inflammation were studied for the condition of local
immunity by determining the urine content of secretory
immunoglobulin A (SIgA) under conditions of combined treatment with
making use of phlogenzyme, a drug of II-generation systemic
enzymotherapy (SE). Recordable in this patients population was a
marked increase in the urine
level of SIgA. Incorporation in a combined treatment of phlogenzyme
results in normalizing the status of the urinary system local
immunity. Evidence has been obtained on the lack of parallelism in
the dynamics between the serum IgA content and urine concentration
of SIgA, which fact suggests independence of local immunity. Our
theory is that an appreciable increase in the urine level of SIgA in
patients with urolithiasis concurrent with pyelonephritis may have
an important part to play in the genesis of nephrolithiasis.
PMID:
10474953
[PubMed - indexed for MEDLINE]