Therapy of adnexitis - enhancement of the basic antibiotic therapy with hydrolytic enzymes
Dittmar F.-W.1, Weissenbacher E. R.2. Therapy of adnexitis - enhancement of the basic antibiotic therapy with hydrolytic enzymes. International Journal of Experimental and Clinical Chemotherapy 1992: Vol. 5, No. 2, pp. 73-81. 1. Department of Obstetrics and Gynecology, District Hospital Starnberg, Teaching Hospital of the Ludwig-Maximilians-University Munich, W-8130 Starnberg, FRG. 2. Gynecologic Clinic, Clinic Center Großhadern, Ludwig-Maximilians-University Munich, W-8000 Munich 70, FRG. WE 12 (5-03-2) = WE 44 (5-04-2) nìm. Czech translation of abstract.
Abstract: A total of 56 patients were recruited to a randomized
double blind study (28 to the enzymes and placebo group,
respectively) and treated for a period of 28 days in order to
evaluate the effectiveness and tolerance of an enzyme combination
preparation as adjuvant of the initial 6-day basic antibiotic
treatment.At the beginning of the investigation there were no
differences between the enzymes and the placebo group regarding the
parameters characterizing the process of recovery. At the end,
however, such differences were observed: body temperature in the
enzymes group 37.0°C, in the placebo group 37.2°C, p = 0.021; WBC in
the enzymes group 8,800/m l, in the placebo group 10,100/m l, p =
9.52 x 10-6; ESR after 1 h 14.8 mm/h and 19.5 mm/h in the enzymes
and placebo group, respectively, p = 0.003; score for palpable
tumors in the enzymes group 1.0 ("more resistant to touch than
normal on one side") and 3.0 in the placebo group ("bilateral
resistance to touch"), p = 1.28 x 10-7; score for tenderness on
pressure in the enzymes group 0 (nothing abnormal detected) and 2 in
the placebo group (uterus and adnexa), p = 4.42 x 10-7; score for
vaginal discharge in the enzymes group 0 ("white/normal") and 1 in
the placebo group ("slightly purulent and/or sanguineous"), p = 1.39
x 10-6.
The adnexitis score, defined as major criterion of effectiveness,
gave corresponding results: with comparable baseline values (enzymes
= 12.2, placebo = 11.3, p = 0.08) it was 2.6 in the enzymes group (subacute
adnexitis) and 7.7 in the placebo group (moderate adnexitis) at the
end of therapy (p = 7.45 x 10-7).