Systemic enzyme therapy of
lower limb postphlebitic syndrome
Koshkin V.M., Kirienko A.I., Leontjev
S.G., Agafonov V.F. Systemic enzyme therapy of lower limb
postphlebitic syndrome. Abstract in Russian and Czech. Angiology and
vascular surgery 2000, Vol. 6, No. 2, pp. 61 – 64.
Large clinical material (66 patients) and modern diagnostic
modalities were used for comparative study of systemic enzyme
therapy (Phlogenzym, 2 dragees per 3 times per day for 3 months) and
conventional combined therapy of lower limb postphlebitic syndrome.
Clinical effect of systemic enzyme therapy was more pronounced (84%
for systemic enzyme therapy vs 73% for conventional therapy). Better
outcome was provided by significant changes in hemostasis and blood
rheological parameters, especially by increased blood fibrinolytic
activity and inhibited platelet function. These resulted in
facilitation of venous outflow from affected extremity and clinical
regression of chronic venous insufficiency.