New approaches to modern
cardiology based on systemic enzyme therapy.
Kovalenko V.N., Sledzevskaya I.K.,
Ryabokon E.N., Gavrilenko T.I., Terzov A.I. N.D. New approaches to
modern cardiology based on systemic enzyme therapy. Int. J.
Immunotherapy 2001, Vol. XVII, No. 2/3/4, pp. 101-111 - ISSN
0255-9625 218 K/375 (17-10-3)- (19-05-3).
Strazhesko Institute of Cardiology, Academy of Medical Sciences,
Ukraine.
Summary: Enzyme therapy is a modern medical method based on the complex action of targeted mixtures of hydrolytic enzymes on the main pathological processes by nonspecific and specific immune mechanisms. The efficiency of enzyme therapy is supported by studies performed by a group of Ukrainian doctors on the treatment of postmyocardial infarction patients that led to normalization of cholesterol levels. In these studies, the treatment consisted of Wobenzym®. Under the influence of this drug, some of the immune parameters in patients with postmyocardial infarction returned to normal. Nevertheless, many factors of immune inflammation in postmyocardial infarction patients have not yet been researched and the principles of assignment of enzyme therapy during rehabilitation have not been developed. Immune inflammation in postmyocardial infarction patients was investigated and the research concentrated on the influence of enzymes on immune factors during rehabilitation. Seventy-three patients with postmyocardial infarction were divided into two groups: group 1 consisted of 52 patients treated with Wobenzym® for 6 months and group 2 consisted of 21 patients given basic therapy (aspirin, b-blockers and nitrates) only. Material for research was venous blood, which was taken in the morning prior to the beginning of Wobenzym® therapy and again after 1, 3 and 6 months of treatment. Biochemical research included tracing of cholesterol, triglycerides and atherogenic potential. Immunology research included study of the factors of immunity, cytokine levels and immunoinflammatory reaction. Postmyocardial infarction patients showed changes in lipid, immunological and circulatory dynamics. This study concentrated on analyzing the influence of enzyme therapy on changes in lipid, immunological and circulatory dynamics and determination of the efficiency of its extended application. A set of major parameters that are important in myocardial infarction are described. It was found that inclusion of Wobenzym® in the complex treatment of postmyocardial infarction patients is beneficial, as this drug has immuno- and lipid correction effects. Systemic enzyme therapy helps to improve the patient's biochemical and immune abnormalities.