Wobenzym in the complex
treatment of autoimmune thyroiditis
Kvantchakhadze R.G. Wobenzym in the complex treatment of autoimmune
thyroiditis. International Journal on Immunorehabilitation, 2002,
Vol. 4, No. 1, pp. 114. Czech abstract, Russian abstract
40 patients suffering from autoimmune thyroiditis were observed for
6 months. Patients were divided into two groups. 20 patients in the
group I were treated depending on thyroid condition (euthyreosis,
hypothyreosis) with L-tyroxin (25 – 100 mg daily) in combination
with Wobenzym (5 coated tablets three times a day). Patients in the
group II were treated with L-tyroxin only at the above dosage. Both
groups were comparable with regard to age, sex, and
clinical-laboratory parameters. All usual parameters were examined
before treatment, after 1 and 3 months, and at the end of treatment.
Improvement of thyroid parameters at ultrasound examination
(reduction of size, improved tissue structure) and aspiration biopsy
parameters (reduced number of lymphoid and plasmocytoma cells in
cytologic punctuate) as well as significant decrease of blood
thyreotropin level and titers of antibodies against thyreoglobulin
and microsomal fraction accompanied by the improvement of subjective
parameters were found in the group I after 3 months of treatment,
whereas in the group II after 6 months of treatment. In both groups
of patients suffering from hypothyreosis, an impaired lipid
metabolism was found. Treatment of patients in the group I resulted
in a decrease of cholesterol and triglyceride levels, whereas in
patients in the group II there were no significant changes found
during the treatment. In
patients in the group I dosage of L-tyroxin could be lowered after 3
months of treatment, in some cases it could even be discontinued.
Under continuous Wobenzym treatment improved clinical-laboratory
parameters were maintained. Thus, Wobenzym was shown to be
therapeutically
effective in a complex therapy of autoimmune thyroiditis.