Immunomodulation in the treatment of reproduction disturbances
Nouza K., Madar J. Immunomodulation in
the treatment of reproduction disturbances. American Journal of
Reproductive Immunology 2001, Vol. 46, No. 1, pp. 106.
Institute for the Care of Mother and Child, Prague, Czech Republic.
VIII International Congress of Reproductive Immunology, Opatija,
Croatia, July 2 – 6, 2001
Problem
Immune mechanisms play an important role in both male and female
sterility. Even more frequent is the participation of immunity in
autoimmune and alloimmune recurrent abortions. Immunopathologic
reactions occur also in women suffering from preeclampsia and
postclimacteric syndrome. To the important causes of female and male
sterility belong chronic infections in the reproductive system.
Methods of Study
Treatment of all above mentioned disorders involved methods of
immunomodulation, mainly local and systemic glucocorticoids,
repeated high doses of intravenous immunoglobulines, anticoagulants
(aspirin, heparin) and recently also oral enzyme therapy. In
infectious processes, the rational use of antibiotics is inevitable.
Results
Immunomodulation ameliorates healing of male and female sterility,
autoimmune as well as alloimmune recurrent abortions. Significant
progress was also obtained in the treatment of adnexitis and
prostatitis. Here, the clinical or subclinical immunological defect
prompted us to use immunomodulators of chemical or biologic nature
(among the latter, combination of oral animal and plant proteolytic
enzymes). Their use in combination with antibiotics led to a more
frequent and more effective healing not only in the infections
evoked by "common" bacteria, but also in processes caused by
chlamydia, mycoplasma, and ureaplasma.
Conclusion
Immunomodulation represents an important part of the complex therapy
of male and female sterility, recurrent abortions and chronic
infections of the reproductive system.