Our
first experience with utilisation of hydrolytic enzymes in arterior
uveitis
Porubská M. Our first
experience with utilisation of hydrolytic enzymes in arterior
uveitis. Rheumatologia 2000, Roč. 14, č. 2, str. 65-69.
(3-14-1).
Department of Ophthalmology, Institute of Respiratory Diseases, Nový
Smokovec, Slovakia
Objective: New therapeutic methods with lower
adverse effects than those of corticosteroids and immunosuppressive
are seeked for in the treatment of anterior uveitis. The aim of the
monitoring was assess the efficacy of Wobenzym and Phlogenzym in the
anterior uveitis activity and to compare their therapeutic effect
with the effect of high doses of both the system and parabulbar
application of corticosteroids and/or immunosuppressives.
Methods: A group of 29 hospitalized patients with the high activity
of anterior acute and chronic uveitis received enzyme preparations
for 8 weeks and paralelly, decrease of inflammatory activity was
evaluated.
Results: In a group of patients with anterior acute uveitis mostly
associated with ankylosing spondylitis, inflammatory cells from the
eye anterior chamber in patients treated with hydrolytic enzymes got
absorbed on average in 20 days compared to 27 days in the control
group. In the patients with chronic anterior uveitis mostly
associated with juvenile chronic arthritis all the inflammatory
cells in 50 % of the patients treated with Wobenzym got absorbed on
average in 20.3 days, in 60 % of the patients treated with
Phlogenzym they got absorbed on average in 17.3 days with the most
persisting effect and in the control group in 37 % of 'the patients
on average in 30 days. In the patients receiving enzymes. Fibrín and
Tyndal got absorbed in 1 day, in the control group in 4-5 days.
Conclusion: The results suggest that, utilization of hydrolytic
enzymes makes possible to lower the dosage of corticoids and
contributes to shorter time needed for inhibition of the uveitis
inflammatory activity, important especially in children with JCA.
The best results were observed in administration of Phlogenzym.
Key words: hydrolytic enzymes, corticosteroids, anterior chamber,
uveitis.