Efficiency of system enzyme therapy in immunopathological states
Sizyakina
L.P., Efremov V.V. Efficiency of system enzyme therapy in
immunopathological states. International Journal on
Immunorehabilitation 2001, 3, 2, 75.
Rostov State Medical University, Rostov-on-Don, Russia. Proceedings
of the VII International Congress on Immunorehabilitation “Allergy,
Immunology and Global Network : Insight into the New Millennium” New
York, USA, April 14 – 17, 2001
Effíciency of Wobenzyme and Phlogenzyme was
estimated in 102 patients with rheumatoid, 36 patients with
disseminated sclerosis, in children with generalized lymphodenopathy
who often fall ill (junior group, aged 3-5 years - 30 patients;
senior group, aged 6-12 years - 35 patients), and in 30 patients
with pollinosis on the background of specific immunotherapy (SIT).
Positive results were achieved when Wobenzyme was used in
combination with metatrexate as basic therapy in patients with
seropositive rheumatoid arthritis, resistant to routine therapy. A
positive effect of Phlogenzyme was recorded when it was used in
disseminated sclerosis: terms of remission and normalization of the
balance between proliferation and apopthosis were prolonged. The
clinical effíciency of these preparations was registered in children
who often fall ill.
In both age groups positive dynamics of lymphoproliferative syndrome
as well as diminishing of respiratory infection frequency was noted.
The effects of Wobenzyme are: improvement of differentiation
processes with prevailing of mature T lymphocytes, normalization of
immunoregulatory index intensifícation of the processes of
intercellular cooperation and microbicidal activity of neutrophiles.
In patients with pollinosis, SIT + Wobenzyme revealed more vivid
hyposensitization effect as compared to the control, as well as the
possibility to apply higher doses of allergens and to prolong the
intervals between their application. The level of total and
specified IgE in blood serum decreased.