Efficacy and
tolerability of oral enzyme therapy as compared to diclofenac in
active osteoarthrosis of knee joint: an open randomized controlled
clinical trial.
Tilwe GH, Beria S, Turakhia NH,
Daftary GV, Schiess W. Efficacy and tolerability of oral enzyme
therapy as compared to diclofenac in active osteoarthrosis of knee
joint: an open randomized controlled clinical trial. J Assoc
Physicians India. 2001 Jun;49:617-21.
Department of Medicine, GS Medical College and KEM Hospital, Mumbai.
Tilwe2001-65
OBJECTIVE: To compare the efficacy and tolerability of an
oral enzyme preparation(Phlogenzym) with that of an NSAID (diclofenac)
in the treatment of active osteoarthrosis. METHODS: Prospective,
randomized, controlled, single-blind study of seven weeks duration
at a tertiary care centre wherein 50 patients aged 40-75 years, with
activated osteoarthrosis of knee joint were randomized to receive
phlogenzym tablets (2-3 tablets, bid) or diclofenac sodium 50 mg bid
for three weeks. RESULTS: At the end of therapy (three weeks) and at
follow-up visit at seven weeks there was reduction in pain and joint
tenderness and swelling in both groups, and slight improvement in
the range of movement in the study group. There duction in joint
tenderness was greater (p < 0.05) in the study group receiving
phlogenzym.
CONCLUSION: Phlogenzym is as efficacious and well tolerated as
diclofenac sodium in the management of active osteoarthrosis over
three weeks of treatment.
PMID:
11584936
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