Prophylactic administration of Wobenzym to reduce consequences of sports injuries in karate fighters Randomized double-blind placebo controlled study
Zuschlag J.-M. Prophylactic administration of Wobenzym to reduce
consequences of sports injuries in karate fighters. MUCOS Pharma
GmbH & Co, Dept. Clinical Research, Geretsried, Germany.
In a double blind, placebo controlled, randomised clinical trial the
efficacy and tolerance of WOBENZYM® adminstration was
proved to reduce the consequences of sports injuries in top
sportsmen.
20 karate fighters, aged between 13 and 21 years, who underwent a
regular training, were included into the trial. 10 volunteers
received in the Phase I Wobenzym tablets and in the Phase II
placebo, whereas other 10 sportsmen received in the Phase I placebo
and in the Phase II Wobenzym.
Main evaluation criteria were training absence and absence at work
or at school.
Other criteria were duration of hematomas, edema, rest pain, pain on
movement, pain on pressure, restricted motility and general
inflammatory reactions.
Frequency as well as severity of symptoms were comparable in both
groups.
However, their duration was statistically significantly shorter
under Wobenzym treatment. Evaluation of main criteria was
statistically significantly better in the enzyme group (training
absence 2.2 days compared to 9.5 days in the placebo group, p = 2.87
x 10-6; absence at work or at school 0.2 days compared to 1.8 days,
p = 0.024). Evaluation of all other criteria showed statistically
significantly better result in the enzyme group as compared to the
placebo group (p < 0.001).
One case of adverse events was reported in the enzyme group: a
slight diarrhea which lasted for five days and did not require any
changes of the therapy. There was a possible association with
Wobenzym treatment.